MEDI-SPA IN A BOTTLE: SHISEIDO Launches the First Serum to Clinically Replace Facial Fillers

Cancel that medi-spa appointment, the future of skincare has arrived. Introducing Bio-Performance Skin Filler Serums, Shiseido’s most advanced skincare innovation to date. Powered by Shiseido’s proprietary and breakthrough MolecuShift Technology, the two-step system acts like an injectable filler that visibly improves wrinkles, fine lines, and loss of firmness. It also helps skin gradually accumulate Hyaluronic Acid for long-lasting effects.

Shiseido was the first cosmetics company to produce highly safe, high-quality Bio-Hyaluronic acid of natural origin with 2x more moisturizing power. Over the past 40 years, Shiseido has continued to innovate and lead in Hyaluronic Acid development.

Normally, Hyaluronic Acid molecules are big and hydrate while remaining only on the surface. Although other technologies can break down the Hyaluronic Acid molecules to penetrate deeper into the skin, this lowers the efficacy and advantages of the Hyaluronic Acid.

Revolutionary Technology

Shiseido’s innovative MolecuShift Technology successfully shrinks the size of Hyaluronic Acid molecules and reverts them back to their original size without changing the structure. This allows Hyaluronic Acid to penetrate deep into the skin without compromising any of its advantages.

  • Infill Serum (for night) contains shrunken Hyaluronic Acid molecules which are delivered into deep layers of the skin’s stratum corneum.
  • Full Expansion Serum (for day) expands Hyaluronic Acid molecules back to

The powerhouse formula also includes:

  • Cinnamon Extract: Helps to optimize skin’s natural purification process.
  • Red Clover Extract: Prevents thinning of the epidermis.
  • Chai Hu Extract: Promotes collagen and hyaluronic acid production for firming
  • benefits.

May be used in place of or in conjunction with injectable fillers to complement results.


Step by Step:

  • Apply before moisturizer. When using with other serums, apply Bio-Performance Skin Filler Serums as the last serum before your moisturizer.
  • In the evening, pump Infill Serum once onto fingertips and smooth evenly over
  • face and neck.
  • In the morning, pump Full Expansion Serum once onto fingertips and smooth
  • evenly over the face and neck.
  • For Refills: Save the pumps and caps from your original bottles. Insert the pump into the refill, then close cap.

In two weeks, skin elasticity is improved while wrinkles on cheek, under-eye area, nasolabial folds, and crow’s feet are diminished.*

Clinical Studies:

After 1 day (day and night use):

  • 92% said skin looks more volumized than ever
  • 71% said their face looks 5 years younger.
  • 91% said the forehead looks firmer
  • 85% said fine lines are less visible
  • 81% said nasolabial folds are less visible
  • 87% said the chin looks firmer
  •  91% said my skin looks firmer as if I had a medical treatment
  • 95% said I like this serum more than medical cosmetics
  •  99% said serum feels effective when used with medical cosmetics
  •   97% said serum feels safer to use than medical injectables

After 2 weeks:

  • Skin elasticity is improved
  • Wrinkles on cheek, undereye area, nasolabial folds, and crow’s feet are diminished

After 4 weeks:

  • Skin is visibly more plumped


Don’t let youthful skin slip away. Click here to shop the new Bio-Performance Skin Filler Serums Collection